In short, the main differences between FDA approved, food-grade, and NSF-certified are as follows: FDA approved: Primarily applies to drugs, medical devices, and certain food additives; indicates that the FDA has approved the product for a specific intended use. Food-grade: Refers to materials and substances safe for direct contact with food; ensures they meet regulatory standards for food safety and prevent contamination. NSF-certified: A certification provided by NSF International, typically related to equipment and materials used in the food industry; indicates that the product meets specific safety, quality, and performance standards set by NSF.